By discussion, this new amino acid deposits of the hLHR and hFSHR was numbered in the initiator methionine of their precursor sequences acquired of the digital interpretation of your own open studying structures of cognate DNA (cDNA). 211,212 Formulas you to definitely anticipate the most likely site away from cleavage out-of laws peptides assume them to be between deposits 24 and you may twenty-five of hLHR and you can residues 17 and 18 of the hFSHR. And the Letter-terminus of the mature hLHR and you may hFSHR is forecast is Leu25 and you may Cys18 respectively. 4 .
When grouped with the TSH receptor, the gonadotropin receptors form the glycoprotein hormone receptor family. One can readily recognize three distinct domains in this family of receptors, a large N-terminal domain that contains about 300 residues and is predicted to be extracellular, a serpentine region containing seven transmembrane segments connected by three extracellular loops and three intracellular loops, and a C-terminal tail that is predicted to be located intracellularly ( Fig. 2.4 ). The presence of seven transmembrane segments suggests that the gonadotropin receptors are members of the superfamily of G protein-coupled receptors (GPCRs).