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34 Conclusions from this studies may provide it is possible to explanations getting contradictory contributes to earlier degree researching the end result out-of calcium supplements with the colorectal carcinogenesis. 6,8,9,10,35,thirty-six An earlier analysis hypothesised that chemo-preventive negative effects of calcium supplements intake to the CRC will get generally use its effects just in the beginning (we.e., adenoma). 16 Our very own conclusions try consistent with earlier epidemiologic data, fifteen,37 suggesting higher calcium consumption may only inhibit very early colorectal carcinogenesis at phase from incident adenoma 6,seven,8,9,ten,15 in addition to relationship tends to be healthier for reduction off experience complex adenoma, a good premalignant lesion to own CRC, fifteen than many other brand of adenoma/polyps. 38 The possibility are similar to the observance that the magnitude out of reduction in total CRC exposure associated with high calcium consumption is a lot like the reduction in adenoma risk.